Research

Our aim is to examine the potential mechanisms contributing to perioperative neurocognitive disorders in an older surgical population, with the hypothesis that the blood brain barrier will be altered, contributing to brain tissue changes in cognitive control areas.

We will examine a low-cost thiamine intervention in older coronary heart disease patients, which has direct public health implications and could reduce cognitive deficits, and thus, dramatically impact the morbidity, mortality, early dementia and Alzheimer’s disease risk, and quality of life in this high-risk older adult patient population.

Our aim is to examine mitochondrial and oxidative stress mechanisms contributing to changes in brain metabolites and antioxidant, reduced CBF in cognitive regulatory areas, and serum inflammatory biomarkers, as well as links among these measures in SVHD patients.

We will examine the nature and types of brain injury, regional cerebral blood flow (CBF) changes, and neural responses to cognitive challenge, and whether brain tissue changes, altered CBF, and diminished neural responses, as well as mood and cognitive functions recover after adenotonsillectomy in pediatric obstructive sleep apnea will be examined.

We will examine whether a low-cost thiamine intervention can improve blood brain barrier function and reduce mood and cognition deficits in Type 2 diabetes mellitus adults